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KMID : 0616120090400040382
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 4 p.382 ~ p.387
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Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (3)
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Jeong Il-Ha
Kim Jong-Min
Jang Dae-Sik
Kim Joo-Hwan
Cho Jung-Hee
Kim Jin-Sook
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Abstract
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Enhanced formation and accumulation of advanced glycation end products (AGEs) have been implicated as a
major pathogenesis process leading to diabetic complications, normal aging, atherosclerosis and Alzheimer’s disease. In our ongoing project to discover novel treatments for diabetic complications from natural sources, we have investigated on the inhibitory activity of 67 ethanol extracts from 57 Korean herbal medicines against the formation of AGEs in vitro. Of these, 22 extracts were found to have a significant AGEs inhibitory activity (IC50<50 μg/ml) compared with aminoguanidine (IC50=75.98 μg/ml). Particularly, 6 extracts from 3 herbal medicines, Castanea crenata (flower, leaf, bark-twig), Acer tatarium subsp. ginnala (fruit) and Sapium japonicum (leaf, twig) showed (approximately 8-17 fold) stronger inhibitory activity than that of aminoguanidine.
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KEYWORD
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Advanced glycation end products, AGEs, diabetic complications, Korean herbal medicines
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